Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi

James M. Wood, Nishikant Satam, Renata G. Almeida, Vinicius S. Cristani, Dênis Pires de Lima, Luíza Dantas-Pereira, Kelly Salomão, Rubem F. S. Menna‐Barreto, Irishi N. N. Namboothiri, John F. Bower, Eufrânio N. da Silva Júnior

2020Bioorganic & Medicinal Chemistry26 citationsDOI Open Access PDF

Topics & Concepts

ChemistryBenznidazolePhthalideAnnulationTrypanosoma cruziChagas diseaseChemical synthesisStereochemistryBicyclic moleculeNitroalkeneQuinoneAntiparasiticCombinatorial chemistryOrganic chemistryCatalysisBiochemistryEnantioselective synthesisIn vitroParasite hostingVirologyPathologyWorld Wide WebMedicineComputer scienceBiologyTrypanosoma species research and implicationsSynthesis and Biological EvaluationSynthesis and Catalytic Reactions

Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi

Topics & Concepts

Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi