Fecal Microbiota Was Reshaped in UCP1 Knock-In Pigs via the Adipose-Liver-Gut Axis and Contributed to Less Fat Deposition
Jianfei Pan, Linya Chui, Tianxia Liu, Qiantao Zheng, Xuexue Liu, Lulu Liu, Ying Zhao, Lilan Zhang, Min Song, Jianlin Han, Jiaojiao Huang, Chaohua Tang, Cong Tao, Jianguo Zhao, Yanfang Wang
Abstract
, and the metabolite HDCA were found to be significantly increased in feces of UCP1 pigs and had a negative relationship with backfat thickness. Mice with fecal microbiota transplantation phenocopied the UCP1 pigs under both CD and HFD conditions, suggesting that the fecal microbes of UCP1 pigs participate in regulating host lipid metabolism. Our study provides new data regarding the cross talk between host genetic variations and the gut microbiota and paves the way for the potential application of microbes or their metabolic production in the regulation of fat deposition in pigs.