Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance
Haiyan Wang, Min Huang, Wenying Wang, Yu Zhang, Xiaqing Ma, Limin Luo, Xiaotao Xu, Liang Xu, Haibo Shi, Yongming Xu, Aizhong Wang, Tao Xu
Topics & Concepts
TLR4MicrogliaNeuroinflammationPharmacologyPhosphorylationMorphineNociceptionSignal transductionMedicineReceptorChemistryInflammationInternal medicineBiochemistryPain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyNeuroinflammation and Neurodegeneration Mechanisms