Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity
Seyed–Omar Zaraei, Nour N. Alach, Hanan S. Anbar, Randa El‐Gamal, Hamadeh Tarazi, Rimas T. Tokatly, Rawan R. Kalla, Mouna A. Munther, Marwa M. Wahba, Aya M. Al-Shihabi, Mahmoud K. Shehata, Rawan M. Sbenati, Afnan I. Shahin, Raafat El‐Awady, Taleb H. Al‐Tel, Mohammed I. El‐Gamal
Topics & Concepts
ChemistrySorafenibPotencyQuinolineKinaseCell cultureStereochemistryApoptosisIC50Cell growthPharmacologyBiochemistryIn vitroCancer researchBiologyGeneticsOrganic chemistryHepatocellular carcinomaMelanoma and MAPK PathwaysSynthesis and biological activityComputational Drug Discovery Methods