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Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity

Seyed–Omar Zaraei, Nour N. Alach, Hanan S. Anbar, Randa El‐Gamal, Hamadeh Tarazi, Rimas T. Tokatly, Rawan R. Kalla, Mouna A. Munther, Marwa M. Wahba, Aya M. Al-Shihabi, Mahmoud K. Shehata, Rawan M. Sbenati, Afnan I. Shahin, Raafat El‐Awady, Taleb H. Al‐Tel, Mohammed I. El‐Gamal

2022European Journal of Medicinal Chemistry32 citationsDOIOpen Access PDF

Topics & Concepts

ChemistrySorafenibPotencyQuinolineKinaseCell cultureStereochemistryApoptosisIC50Cell growthPharmacologyBiochemistryIn vitroCancer researchBiologyGeneticsOrganic chemistryHepatocellular carcinomaMelanoma and MAPK PathwaysSynthesis and biological activityComputational Drug Discovery Methods
Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity | Litcius