The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead
Kim‐Anh Nguyen, Louise Conilh, Pierre Falson, Charles Dumontet, Ahcène Boumendjel
Topics & Concepts
ChemistryWarheadGPX4DoxorubicinProgrammed cell deathConjugateReactive oxygen speciesSelenocysteineBiochemistryGlutathioneCancer researchApoptosisCysteineGlutathione peroxidaseEnzymeBiologyEngineeringMathematicsGeneticsChemotherapyMathematical analysisAerospace engineeringFerroptosis and cancer prognosisCancer, Lipids, and MetabolismInflammatory mediators and NSAID effects