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Rhodium‐Catalyzed Spiro Indenyl Benzoxazine Synthesis via C‐H Activation/Annulation of 3‐Aryl‐2<i>H</i>‐Benzo[<i>b</i>][1,4]oxazines and Alkynes

Heng Tan, Ronibala Devi Laishram, Xuexin Zhang, Guangrui Shi, Kangkui Li, Jingchao Chen

2020European Journal of Organic Chemistry22 citationsDOI

Abstract

The rhodium (III)‐catalyzed annulation of 3‐Aryl‐2 H ‐Benzo[ b ][1,4]oxazines with alkynes via C–H activation has been developed. This reaction afforded a series of spiro indenyl benzoxazine in high yields under mild reaction condition with good functional group tolerance.

Topics & Concepts

ChemistryAnnulationOxazinesRhodiumCatalysisArylMedicinal chemistryStereochemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Alkyne Reactions
Rhodium‐Catalyzed Spiro Indenyl Benzoxazine Synthesis via C‐H Activation/Annulation of 3‐Aryl‐2<i>H</i>‐Benzo[<i>b</i>][1,4]oxazines and Alkynes | Litcius