The importance of lean mass and iron deficiency when comparing hemoglobin mass in male and female athletic groups
Jesse A. Goodrich, Dillon J. Frisco, Sewan Kim, Marissa Holliday, Miguel Rueda, Sourav Poddar, William C. Byrnes
Abstract
Differences in hemoglobin mass (Hbmass) between groups and across sex are primarily due to differences in lean mass. Iron deficiency (ID) independently decreases Hbmass; this effect is best characterized with Hbmass relative to lean mass. ID is common in females and is associated with lower hepcidin and elevated erythroferrone but not with differences in inflammatory cytokines. Hbmass relative to lean mass accurately quantifies hematological alterations secondary to iron deficiency.
Topics & Concepts
HemoglobinLean body massIron deficiencyFat massInternal medicineEndocrinologyMedicineBody mass indexPsychologyAnemiaBody weightBody Composition Measurement TechniquesIron Metabolism and DisordersThermoregulation and physiological responses