Bergenin as a Novel Urate-Lowering Therapeutic Strategy for Hyperuricemia
Mo Chen, Chenyi Ye, Jianing Zhu, Peiyu Zhang, Yujie Jiang, Xiaoyong Lu, Huaxiang Wu
Abstract
expression in HK-2 cells by inhibiting the nuclear translocation of p53. Furthermore, bergenin decreased the serum levels of IL-6, IL-1β, and TNF-α in hyperuricemia mice, and promoted a polarization shift from the M1 to M2 phenotype in RAW264.7 cells. In conclusion, these findings provide evidence supporting the further development of bergenin as a novel therapeutic strategy for hyperuricemia.
Topics & Concepts
HyperuricemiaMedicineGoutPharmacologyUric acidIntensive care medicineInternal medicineGout, Hyperuricemia, Uric AcidResearch on Leishmaniasis StudiesDrug-Induced Hepatotoxicity and Protection