Enhanced Bone Regeneration through Regulation of Mechanoresponsive FAK-ERK1/2 Signaling by ZINC40099027 during Distraction Osteogenesis
Shanyu Li, Hongxiao Wu, Feng Wang, Lingchi Kong, Yifan Yu, Rongtai Zuo, Haoyu Zhao, Jia Xu, Qinglin Kang
Abstract
Our results show that ZN27 targets FAK-ERK1/2 signaling to stimulate both angiogenesis and osteogenesis, and ZN27 accelerates bone regeneration in DO, suggesting the therapeutic potential of ZN27 for repairing large bone defects in the mechanobiological environment during DO.
Topics & Concepts
AngiogenesisRegeneration (biology)Mesenchymal stem cellChemistryCell biologyDistraction osteogenesisNeovascularizationCancer researchBiologyNeuroscienceDistractionCraniofacial Disorders and TreatmentsBone Metabolism and DiseasesCongenital heart defects research