Impaired T‐cell responses in domestic pigs and wild boar upon infection with a highly virulent African swine fever virus strain
Jane Hühr, Alexander Schäfer, Theresa Schwaiger, Laura Zani, Julia Sehl‐Ewert, Thomas C. Mettenleiter, Sandra Blome, Ulrike Blohm
Abstract
effector cells observed. Furthermore, a T-bet-dependent activation of the remaining CD8 T cells did not occur. In contrast, a T-cell response could be observed in wild boar at 5 days post-inoculation in the blood and in tendency also in some organs. However, this cytotoxic response was not beneficial as all wild boars showed a severe acute lethal disease and a higher proportion died spontaneously or was euthanized at the humane endpoint.
Topics & Concepts
Wild boarAfrican swine fever virusBiologyCytotoxic T cellImmune systemDomestic pigVirulenceCD8VirusVirologyAfrican swine feverImmunologyT cellClassical swine feverPathogenesisIn vitroGeneBiochemistryEcologyForestryGeographyAnimal Disease Management and EpidemiologyT-cell and Retrovirus StudiesVector-Borne Animal Diseases