Smartphone-based label-free photoelectrochemical sensing of cysteine with cadmium ion chelation
Yaru Li, Guang Liu, Daizong Ji, Yan He, Qingmei Chen, Fenni Zhang, Qingjun Liu
Abstract
/cysteine chelate complex served as the electron acceptor for sensitive PEC sensing under low-power LED illumination. A portable PEC system was developed for quantitative detection of cysteine by integrating the PEC sensor, a self-designed detection circuit and a smartphone. The detected photocurrents changed linearly with the cysteine concentrations ranging from 0 μM to 40 μM, and the limit of detection is calculated to be 9.2 μM. To demonstrate the capability of this system, cysteine in spiked urine samples was quantified with a recovery rate of 96.1%-100.57%. This system provides high portability, sufficient accuracy and sensitivity, and greatly reduces the complexity and cost of point-of-care cysteine detection.