Near‐Infrared‐II Semiconducting Polymer Dots for Deep‐tissue Fluorescence Imaging
N.M. Gupta, Yang‐Hsiang Chan, Sampa Saha, Ming‐Ho Liu
Abstract
Fluorescence imaging, particularly in the NIR-II region (1000-1700 nm), has become an unprecedented tool for deep-tissue in vivo imaging. Among the fluorescent nanoprobes, semiconducting polymer nanoparticles (Pdots) appear to be a promising agent because of their tunable optical and photophysical properties, ultrahigh brightness, minimal autofluorescence, narrow-size distribution, and low cytotoxicity. This review elucidates the recent advances in Pdots for deep-tissue fluorescence imaging and the facing future translation to clinical use.
Topics & Concepts
AutofluorescenceFluorescenceFluorescence-lifetime imaging microscopyPolymerMaterials scienceNanotechnologyBrightnessNanoparticleOptical imagingNear-infrared spectroscopyBiophysicsOpticsBiologyPhysicsComposite materialNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsCarbon and Quantum Dots Applications