Neutrophil extracellular trap-mediated impairment of meningeal lymphatic drainage exacerbates secondary hydrocephalus after intraventricular hemorrhage
Qiang Zhang, Yujie Chen, Yingpei Li, Zhou Feng, Liang Liang, Xiaoke Hao, Wenbo Kang, Zhaoqi Zhang, Xuyang Zhang, Rong Hu, Hua Feng, Zhi Chen
Abstract
Our findings indicated that mLVs participate in the development of brain injury and secondary hydrocephalus after IVH and that NETs contribute to acute LEC injury and lymphatic thrombosis. CX3CR1 is a key molecule in NET-induced LEC damage and meningeal lymphatic thrombosis, which leads to mLV dysfunction and exacerbates hydrocephalus and brain injury. NETs may be a critical target for preventing the obstruction of meningeal lymphatic drainage after IVH.
Topics & Concepts
HydrocephalusMedicineIntraventricular hemorrhageCerebrospinal fluidLymphatic systemThrombosisAnesthesiaPathologyInternal medicineSurgeryBiologyPregnancyGestational ageGeneticsCerebrospinal fluid and hydrocephalusIntracerebral and Subarachnoid Hemorrhage ResearchTraumatic Brain Injury and Neurovascular Disturbances