Topical glaucoma medications – Clinical implications for the ocular surface
Fredrik Fineide, Neil Lagali, Muhammed Yasin Adil, Reiko Arita, Miriam Kolko, Jelle Vehof, Tor Paaske Utheim
Abstract
Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound. A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pharmaceutical compounds on the ocular surface, with resultant tear film instability and dry eye disease. Herein, we critically appraise the published literature exploring the effects of preservatives and pharmaceutical compounds on the ocular surface.
Topics & Concepts
GlaucomaOphthalmologyMedicineIntraocular pressureBlindnessTopical medicationGlaucoma medicationLatanoprostCorneal diseaseOptometryDermatologyCorneaOcular Surface and Contact LensGlaucoma and retinal disordersOcular Infections and Treatments