Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression
Andréa L. Rocha, Tanes Lima, Gerson S. Profeta, Renan Oliveira Corrêa, Danilo Lopes Ferrucci, Bruno Rodrigues, Camila M. Lopes‐Ramos, Daniel Nilsson, Thiago L. Knittel, Pollyana Ribeiro Castro, Mariane Font Fernandes, Flaviano S. Martins, Raphael B. Parmigiani, Leonardo R. Silveira, Hernandes F. Carvalho, Johan Auwerx, Marco Aurélio Ramirez Vinolo, Jérémie Boucher, Marcelo A. Mori
Abstract
), thus increasing FGF21 signaling and promoting beige adipogenesis. Our data demonstrate that enoxacin counteracts obesity by promoting thermogenic signaling and inducing oxidative metabolism in adipose tissue and skeletal muscle in a mechanism that involves, at least in part, miRNA-mediated regulation.
Topics & Concepts
EnoxacinAdipose tissueEnergy metabolismOxidative metabolismmicroRNAOxidative phosphorylationFunction (biology)MetabolismOxidative stressObesityChemistryCell biologyMedicinePharmacologyEndocrinologyBiologyAntibioticsBiochemistryGeneCiprofloxacinNorfloxacinAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesImmune Cell Function and Interaction