Design, synthesis and pharmacological characterization of aminopyrimidine derivatives as BTK/FLT3 dual-target inhibitors against acute myeloid leukemia
Fansheng Ran, Yun Liu, Jian Zhu, Xuexian Deng, Hongmei Wu, Weizhi Tao, Xudong Xie, Yirong Hu, Yanan Zhang, Yong Ling
Topics & Concepts
Bruton's tyrosine kinaseChemistryMyeloid leukemiaTyrosine kinasePharmacologyIC50Cancer researchCD135BiochemistryIn vitroSignal transductionBiologyAcute Myeloid Leukemia ResearchChronic Lymphocytic Leukemia ResearchProtein Degradation and Inhibitors