Synthesis of biologically active [1,5]diazocino[2,1-<i>b</i>]quinazolinones through [4 + 4] cycloaddition of 2-alkynyl quinazolinones with aza-<i>ortho</i>-quinone methides
Li Pang, Shu-Jun Fang, Pei‐Sen Zou, Wang Wang, Jun‐Cheng Su, Xiaoqing Liu, Cheng‐Xue Pan, Dong‐Liang Mo, Gui‐Fa Su
Abstract
Biologically active [1,5]diazocino[2,1- b ]quinazolinones were synthesized via base-promoted [4 + 4] cycloaddition of 2-alkynyl quinazolinones with aza- ortho -quinone methides.
Topics & Concepts
ChemistryCycloadditionQuinoneCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsMulticomponent Synthesis of Heterocycles