Engineered Oncolytic Adenoviruses: An Emerging Approach for Cancer Therapy
Ee Wern Tan, Noraini Abd-Aziz, Chit Laa Poh, Kuan Onn Tan
Abstract
Cancer is among the major leading causes of mortality globally, and chemotherapy is currently one of the most effective cancer therapies. Unfortunately, chemotherapy is invariably accompanied by dose-dependent cytotoxic side effects. Recently, genetically engineered adenoviruses emerged as an alternative gene therapy approach targeting cancers. This review focuses on the characteristics of genetically modified adenovirus and oncology clinical studies using adenovirus-mediated gene therapy strategies. In addition, modulation of the tumor biology and the tumor microenvironment as well as the immunological responses associated with adenovirus-mediate cancer therapy are discussed.
Topics & Concepts
Oncolytic adenovirusOncolytic virusGenetic enhancementCancerTumor microenvironmentCancer therapyCancer researchMedicineChemotherapyImmunologyBiologyOncologyGeneInternal medicineGeneticsVirus-based gene therapy researchCancer Research and TreatmentsCAR-T cell therapy research