Effects of SGLT2 Inhibitors on Ion Homeostasis and Oxidative Stress associated Mechanisms in Heart Failure
Gloria M. Gager, Dirk von Lewinski, Harald Sourij, Bernd Jilma, Ceren Eyileten, Krzysztof Filipiak, Martin Hülsmann, Jacek Kubica, Marek Postuła, Jolanta M. Siller‐Matula
Abstract
signaling and oxidative stress accompanied by excessive reactive oxygen species (ROS) production, fibrosis and inflammatory processes form cornerstones of potential molecular targets for SGLT2 inhibitors. This review focused on three hypotheses for SGLT2 inhibitor-mediated cardioprotection: ion homeostasis, oxidative stress and endothelial dysfunction.
Topics & Concepts
Oxidative stressCardioprotectionRenal glucose reabsorptionReactive oxygen speciesMedicinePharmacologyEndothelial dysfunctionDiabetes mellitusDapagliflozinCotransporterGlycemicGlucose homeostasisType 2 diabetesHomeostasisEndocrinologyChemistryInternal medicineBiochemistrySodiumInsulin resistanceIschemiaOrganic chemistryDiabetes Treatment and ManagementAdvanced Glycation End Products researchPancreatic function and diabetes