Local IP <sub>3</sub> receptor–mediated Ca <sup>2+</sup> signals compound to direct blood flow in brain capillaries
Thomas A. Longden, Amreen Mughal, Grant W. Hennig, Osama F. Harraz, Bo Shui, Frank K. Lee, Jane C. Lee, Shaun Reining, Michael I. Kotlikoff, Gabriele M. König, Evi Kostenis, David C. Hill‐Eubanks, Mark T. Nelson
Abstract
-dependent synthesis of nitric oxide increases local blood flow selectively through affected capillary branches, providing a mechanism for high-resolution control of blood flow to small clusters of neurons.
Topics & Concepts
Blood flowCalciumCerebral blood flowReceptorBlood–brain barrierCapillary actionChemistryBiophysicsNeuroscienceMaterials scienceBiologyCentral nervous systemMedicineBiochemistryInternal medicineComposite materialOrganic chemistryNeuroscience and Neuropharmacology ResearchIon channel regulation and functionErythrocyte Function and Pathophysiology