P2X7 receptor is essential for cross-dressing of bone marrow-derived dendritic cells
Carlos Barrera‐Avalos, Pedro Briceño, Daniel Valdés, Mónica Imarai, Elías Leiva‐Salcedo, Leonel E. Rojo, Luis A. Milla, J. Pablo Huidobro‐Toro, Claudia Robles-Planells, Alejandro Escobar, Francesco Di Virgilio, Gabriel Morón, Daniela Sauma, Claudio Acuña‐Castillo
Abstract
assays, we found that the P2X7R in both ACs and BMDCs is required to induce membrane and fully functional peptide/MHC complex transfer to BMDCs. These findings show that acquisition of ACs-derived preformed antigen/MHC-I complexes by BMDCs requires P2X7R expression.
Topics & Concepts
Antigen presentationMajor histocompatibility complexCross-presentationCell biologyAntigen-presenting cellAntigen processingAntigenContext (archaeology)Immune systemBone marrowDendritic cellImmunologyT cellMHC class IChemistryBiologyPaleontologyAdenosine and Purinergic SignalingImmune Cell Function and InteractionImmunotherapy and Immune Responses