Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification
Needa Brown, Paul Rocchi, Léna Carmès, Romy Guthier, Meghna Iyer, Léa Seban, Toby Morris, Stephanie Bennett, Michael Lavelle, Johany Peñailillo, Ruben D. Carrasco, Christopher B. Williams, Elizabeth Huynh, Zhaohui Han, Evangelia Kaza, Tristan Doussineau, Sneh M. Toprani, Xingping Qin, Zachary D. Nagel, Kristopher A. Sarosiek, Agnès Hagège, Sandrine Dufort, Guillaume Bort, François Lux, Olivier Tillement, Ross Berbeco
Abstract
We confirmed the safety and enhanced efficacy of AGuIX-Bi with radiation therapy at the selected ratio of 30Gd/70Bi. These results provide crucial evidence towards patient translation.
Topics & Concepts
In vivoNanoparticleRadiation therapyToxicityMagnetic resonance imagingMaterials scienceChemistryNuclear medicineMedicineNanotechnologyInternal medicineRadiologyBiotechnologyBiologyRadiation Therapy and DosimetryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics