High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men
Jonathan S. T. Woodhead, Randall F. D’Souza, Christopher P. Hedges, Junxiang Wan, Michael V. Berridge, David Cameron‐Smith, Pinchas Cohen, Anthony J. Hickey, Cameron J. Mitchell, Troy L. Merry
Abstract
Small regulatory peptides encoded within the mitochondrial genome (mitochondrial derived peptides) have been shown to have cellular cyto- and metabolo-protective roles that parallel those of exercise. Here we provide evidence that humanin and SHLP6 are exercise-sensitive mitochondrial derived peptides. Studies to determine whether mitochondrial derived peptides play a role in regulating exercise-induced adaptations are warranted.
Topics & Concepts
Mitochondrial DNAMitochondrionPeptideBiologyCell biologyInternal medicineEndocrinologyGeneGeneticsBiochemistryMedicineGDF15 and Related BiomarkersNutrition and Health in Aging