Fabrication of stimuli-responsive nanogels for protein encapsulation and traceless release without introducing organic solvents, surfactants, or small-molecule cross-linkers
Yue Zhang, Daowen Zhang, Jin‐Tao Wang, Xiaojie Zhang, Yongfang Yang
Abstract
Stimuli-responsive nanogels were fabricated by reaction of proteins and polymers without using small-organic-molecules. Once the nanogels dissociated, the proteins were released with functional groups, secondary structures, and activities maintained.
Topics & Concepts
ChemistrySmall moleculeMoleculePolymerCombinatorial chemistryOrganic moleculesEncapsulation (networking)BiophysicsPolymer chemistryChemical engineeringOrganic chemistryBiochemistryComputer networkComputer scienceEngineeringBiologyHydrogels: synthesis, properties, applicationsNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems