Flumequine-loaded titanate nanotubes as antibacterial agents for aquaculture farms
Tarek Baâti, Mounir Ben Brahim, Abir Salek, Mouna Selmi, Leïla Njim, Polona Umek, Aı̈cha Aouane, Mohamed Hammami, Karim Hosni
Abstract
). Thanks to its physical properties (diameter 10 nm, tubular shape…) and its high stability in the simulated intestinal medium, TiNTs are easy internalized by enterocytes, thus involving an endocytosis mechanism, and then improve intestinal permeation of FLUM. Taken together, FLUM@TiNTs hold potential as an effective approach for enhancing the antimicrobial activity of FLUM and pave the way not only for future pharmacokinetic studies in the treatment and targeting of fish infections but also for instating of novel strategies that overcome the challenges associated with the abusive use of antibiotics in fish farming.
Topics & Concepts
NorfloxacinFlumequinePermeationChemistryAntibioticsAntibacterial activityAntimicrobialCefotaximeMicrobiologyNuclear chemistryBacteriaNanotechnologyCiprofloxacinMaterials scienceMembraneBiochemistryBiologyOrganic chemistryEnrofloxacinGeneticsAquaculture disease management and microbiotaAdvanced biosensing and bioanalysis techniquesAquatic life and conservation