Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S.J. Davies
Abstract
1) Angiopoietin-like 4 deficiency in hepatocytes ( Angptl4 LivKO ) does not improve triglyceride phenotypes during high-fat feeding. 2) Angptl4 LivKO mice have improved glucose tolerance after chronic high-fat diet. 3) Angptl4 LivKO mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
Topics & Concepts
Internal medicineEndocrinologyTriglycerideInsulin resistanceANGPTL4Adipose tissueGlucose homeostasisBiologyChemistryInsulinMedicineCholesterolBiochemistryGeneLipid metabolism and disordersDiabetes, Cardiovascular Risks, and LipoproteinsCancer-related molecular mechanisms research