Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action
Marina Marinović, Goran Poje, Ivana Perković, Diana Fontinha, Miguel Prudêncio, Jana Held, Laís Pessanha de Carvalho, Tana Tandarić, Robert Vianello, Zrinka Rajić
Topics & Concepts
ChemistryStereochemistryHarmineAmideCinnamic acidStructure–activity relationshipDruggabilityPlasmodium bergheiCytotoxicityRhodanineIn vitroBiochemistryPharmacologyMalariaMedicineGeneImmunologyBiologySynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsSynthesis and pharmacology of benzodiazepine derivatives