Association between PM2.5-bound metals and pediatric respiratory health in Guangzhou: An ecological study investigating source, health risk, and effect
Yi Zheng, Sili Chen, Yuyang Chen, Jingye Li, Binhe Xu, Tongxing Shi, Qiaoyuan Yang
Abstract
Background The adverse effects of 2.5-μm particulate matter (PM 2.5 ) exposure on public health have become an increasing concern worldwide. However, epidemiological findings on the effects of PM 2.5 -bound metals on children's respiratory health are limited and inconsistent because PM 2.5 is a complicated mixture. Objectives Given the vulnerability of children's respiratory system, aim to pediatric respiratory health, this study evaluated the potential sources, health risks, and acute health effects of ambient PM 2.5 -bound metals among children in Guangzhou, China from January 2017 to December 2019. Methods Potential sources of PM 2.5 -bound metals were detected using positive matrix factorization (PMF). A health risk assessment was conducted to investigate the inhalation risk of PM 2.5 -bound metals in children. The associations between PM 2.5 -bound metals and pediatric respiratory outpatient visits were examined with a quasi-Poisson generalized additive model (GAM). Results During 2017–2019, the daily mean concentrations of PM 2.5 was 53.39 μg/m 3 , and the daily mean concentrations of PM 2.5 -bound metals range 0.03 ng/m 3 [thorium (Th) and beryllium (Be)] from to 396.40 ng/m 3 [iron (Fe)]. PM 2.5 -bound metals were mainly contributed by motor vehicles and street dust. PM 2.5 -bound arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr)(VI), nickel (Ni), and lead (Pb) were found to pose a carcinogenic risk (CR). A quasi-Poisson GAM was constructed that showed there were significant associations between PM 2.5 concentrations and pediatric outpatient visits for respiratory diseases. PM 2.5 was significantly associated with pediatric outpatient visits for respiratory diseases. Moreover, with a 10 μg/m 3 increase in Ni, Cr(VI), Ni, and As concentrations, the corresponding pediatric outpatient visits for respiratory diseases increased by 2.89% (95% CI : 2.28–3.50%), acute upper respiratory infections (AURIs) increased by 2.74% (2.13–3.35%), influenza and pneumonia (FLU&PN) increased by 23.36% (20.09–26.72%), and acute lower respiratory infections (ALRIs) increased by 16.86% (15.16–18.60%), respectively. Conclusions Our findings showed that PM 2.5 and PM 2.5 -bound As, Cd, Co, Cr(VI), Ni, and Pb had adverse effects on pediatric respiratory health during the study period. New strategies are required to decrease the production of PM 2.5 and PM 2.5 -bound metals by motor vehicles and to reduce levels of street dust to reduce children's exposure to these pollutants and thereby increase child health.