Nickel-Catalyzed Reductive Aryl Thiocarbonylation of Alkene via Thioester Group Transfer Strategy
Yunxia Feng, Shimin Yang, Shen Zhao, Daopeng Zhang, Xinjin Li, Hui Liu, Yunhui Dong, Fenggang Sun
Abstract
Herein reported is a nickel-catalyzed reductive aryl thiocarbonylation of alkene via thioester group transfer strategy by using simple and readily available thioesters. In contrast to traditional activation of weaker C(acyl)-S bond, the C(acyl)-C bond of thioester was selectively cleaved to enable this reaction under mild conditions. Furthermore, this approach features operational simplicity and broad substrate scope, providing a complementary and practical route for thioester synthesis without requiring toxic thiol or CO gas.
Topics & Concepts
ChemistryArylAlkeneNickelCatalysisThioesterTransfer hydrogenationReductive eliminationCombinatorial chemistryGroup (periodic table)Organic chemistryAlkylEnzymeRutheniumSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions