Cu-Catalyzed highly regioselective 1,2-hydrocarboxylation of 1,3-dienes with CO<sub>2</sub>
Penglin Zhang, Zhanglang Zhou, Rumeng Zhang, Qian Zhao, Chun Zhang
Abstract
A practical copper-catalyzed highly regioselective 1,2-hydrocarboxylation of terminal 1,3-diene with carbon dioxide has been developed. Under mild reaction conditions, this chemistry afforded 2-benzyl-β,γ-unsaturated acid derivatives as products, which are a kind of important unit for bio-active molecules and versatile precursors for organic synthesis, with good functional group tolerance. The key intermediate in this transformation is illustrated by control experiments.
Topics & Concepts
RegioselectivityChemistryCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisCO2 Reduction Techniques and Catalysts