Facile synthesis of 2-vinylindolines <i>via</i> a phosphine-mediated α-umpolung/Wittig olefination/cyclization cascade process
Shu‐Hui Li, Dan Xu, Hui Yao, Mengting Tan, Xiaoxuan Li, Ming‐Guo Liu, Long Wang, Nianyu Huang, Nengzhong Wang
Abstract
-aminobenzaldehydes and Morita-Baylis-Hillman (MBH) carbonates has been ingeniously developed. This protocol serves as a practical tool for the facile synthesis of a broad range of 2-vinylindolines in moderate to good yields under mild reaction conditions. The applicability of this method was demonstrated with gram-scale reaction and various transformations of the corresponding product.
Topics & Concepts
UmpolungWittig reactionPhosphineCascadeChemistryCombinatorial chemistryProcess (computing)StereochemistryOrganic chemistryComputer scienceCatalysisNucleophileChromatographyOperating systemPhosphorus compounds and reactionsAdvanced Synthetic Organic ChemistrySynthesis and pharmacology of benzodiazepine derivatives