A practical photocatalytic strategy for radical (deuterio)difluoromethylation using imidazolium reagents
Chao Sun, Yinpu Shen, Heyin Li, Zhen Wang, Yifan Li, Mengjun Huang, Zhenlei Zou, Jing Liu, Ao Liu, Yi Pan, Weigang Zhang, Yi Wang
Abstract
H installation in natural products and synthetic bioactive compounds, showing broad substrate compatibility. This establishes a robust deuteration platform for drug discovery.
Topics & Concepts
PhotocatalysisReagentChemistryCombinatorial chemistryCatalysisOrganic chemistryFluorine in Organic ChemistryChemical Reactions and IsotopesInorganic Fluorides and Related Compounds