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Incidence of Precipitated Withdrawal During a Multisite Emergency Department–Initiated Buprenorphine Clinical Trial in the Era of Fentanyl

Gail D’Onofrio, Kathryn Hawk, Jeanmarie Perrone, Sharon Walsh, Michelle R. Lofwall, David A. Fiellin, Andrew A. Herring

2023JAMA Network Open77 citationsDOIOpen Access PDF

Abstract

This cohort study examines the incidence of precipitated withdrawal comparing traditional sublingual buprenorphine with a 7-day extended-release injectable initiated in the emergency department (ED).

Topics & Concepts

FentanylBuprenorphineMedicineIncidence (geometry)Emergency departmentAnesthesiaEmergency medicineClinical trialOpioidPsychiatryInternal medicineReceptorPhysicsOpticsOpioid Use Disorder TreatmentHIV, Drug Use, Sexual RiskSubstance Abuse Treatment and Outcomes
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