Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth
Rui Tang, Emily G. Shuldiner, Marcus R. Kelly, Christopher W. Murray, Jess D. Hebert, Laura Andrejka, Min K. Tsai, Nicholas W. Hughes, Mitchell I. Parker, Hongchen Cai, Yaocheng Li, Geoffrey M. Wahl, Roland L. Dunbrack, Peter K. Jackson, Dmitri A. Petrov, Monte M. Winslow
Topics & Concepts
KRASHRASNeuroblastoma RAS viral oncogene homologBiologyCRISPRCancer researchCancerLung cancerCarcinogenesisGeneticsColorectal cancerMedicineGeneOncologyPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingCRISPR and Genetic Engineering