PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny
Diana Sá da Bandeira, Alastair M. Kilpatrick, Madalena Marques, Mario Gomez-Salazar, Telma Ventura, Zaniah González, Dorota Stefancova, Fiona Rossi, Matthieu Vermeren, Chris S. Vink, Mariana Beltrán, Neil C. Henderson, B. Jung, Reinier van der Linden, Harmen J.G. van de Werken, Wilfred F. J. van IJcken, Christer Betsholtz, Stuart J. Forbes, Henar Cuervo, Mihaela Crisan
Abstract
embryonic precursors give rise to a subset of HSPCs that persist into adulthood. These findings provide crucial information for the controlled production of HSPCs in vitro.
Topics & Concepts
HaematopoiesisCell biologyBiologyProgenitor cellZebrafishStromal cellDorsal aortaStem cellHematopoietic stem cellEmbryonic stem cellPlatelet-derived growth factor receptorFms-Like Tyrosine Kinase 3ImmunologyCancer researchGrowth factorReceptorGeneticsGeneMutationZebrafish Biomedical Research ApplicationsImmune cells in cancerImmune Cell Function and Interaction