Patchouli alcohol suppresses castration-resistant prostate cancer progression by inhibiting NF-κB signal pathways
Jian Cai, Juan Zhao, Ping Gao, Yuguo Xia
Abstract
Background: There is evidence that patchouli alcohol (PA) has cytotoxic effects on human cancer cell lines, including inhibiting cell growth, migration, and invasion. However, the exact molecular mechanism of PA in human castration-resistant prostate cancer (CRPC) cells remains unclear. Methods: . Results: study, PA inhibited tumor growth in the mouse xenograft model. Conclusions: by inducing an apoptosis mechanism and inhibiting NF-κB activity. Our findings may provide therapeutic targets for this malignant tumor.
Topics & Concepts
DU145ApoptosisCancer researchCell growthMolecular biologyChemistryDownregulation and upregulationBiologyCancer cellCancerBiochemistryLNCaPGeneGeneticsNatural product bioactivities and synthesisNF-κB Signaling PathwaysSesquiterpenes and Asteraceae Studies