Hydrostatic Pressure-Regulated Cellular Calcium Responses
Minami Fukuchi, Kotaro Oyama, Hiroaki Mizuno, Akihisa Miyagawa, Kazuya Koumoto, Gaku Fukuhara
Abstract
Hydrostatic pressure control has attracted much attention and presents a still challenging objective from mechanobiological viewpoints. Herein, we reveal the calcium entry processes in HeLa cells by means of hydrostatic pressure spectroscopy. The steady-state fluorescence spectral data comprehensively elucidated the factors controlling the outcomes of the hydrostatic pressure-stimulated calcium entry behavior. The present work leads to a new perspective on ion regulations in living cells and an attractive alternative to conventional mechanostimuli.
Topics & Concepts
Hydrostatic pressureHydrostatic equilibriumCalciumBiophysicsChemistryNanotechnologyMaterials scienceThermodynamicsBiologyPhysicsQuantum mechanicsOrganic chemistryMolecular Sensors and Ion DetectionPhotoreceptor and optogenetics researchLipid Membrane Structure and Behavior