Engineering neurovascular organoids with 3D printed microfluidic chips
Idris Salmon, Sergei Grebenyuk, Abdel Rahman Abdel Fattah, Gregorius Rustandi, Thomas Pilkington, Catherine M. Verfaillie, Adrian Ranga
Abstract
generated vasculature. Upon co-development, vascular cells physically interact with the cerebral organoid and form an integrated neurovascular organoid on chip. This 3D printing-based platform is designed to be compatible with any organoid system and is an easy and highly cost-effective way to vascularize organoids. The use of this platform, readily performed in any lab, could open new avenues for understanding and manipulating the co-development of tissue-specific organoids with vasculature.
Topics & Concepts
OrganoidMicrofluidicsNeurovascular bundle3d printedNanotechnologyEngineeringMaterials scienceBiologyBiomedical engineeringCell biologyAnatomy3D Printing in Biomedical ResearchTissue Engineering and Regenerative MedicineAnatomy and Medical Technology