A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease
Guanglei Lv, Anyang Sun, Minqi Wang, Peng Wei, Ruohan Li, Tao Yi
Abstract
Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer's disease.
Topics & Concepts
FluorescenceStage (stratigraphy)InfraredAlzheimer's diseaseDiseaseChemistryMedicinePathologyBiologyOpticsPhysicsPaleontologyAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery Methods