Comparative Analysis and Data Provenance for 1,113 Bacterial Genome Assemblies
David A. Yarmosh, Juan G. Lopera, Nikhita P. Puthuveetil, Patrick Ford Combs, Amy L. Reese, Corina Tabron, Amanda E. Pierola, James M. Duncan, Samuel R. Greenfield, Robert Marlow, Stephen M. King, Marco A. Riojas, John Bagnoli, Briana Benton, Jonathan L. Jacobs
Abstract
-assembled ASRGs, their respective metadata, and variant analysis using RefSeq genomes as a reference. Although assembly quality in RefSeq has generally improved over time, we found that significant quality issues remain, especially as related to genomic data and metadata provenance. Our work highlights the importance of data authentication and provenance for the microbial genomics community, and underscores the risks of ignoring this issue in the future.
Topics & Concepts
MetadataTraceabilityGenomicsData qualityDiscoverabilityPersonal genomicsData scienceInformation repositoryData curationRefSeqMetagenomicsComputer scienceGenomeBiologyWorld Wide WebGeneticsEngineeringGeneSoftware engineeringMetric (unit)Computer data storageOperations managementOperating systemGenomics and Phylogenetic StudiesBacteriophages and microbial interactionsMolecular Biology Techniques and Applications