Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants
Yingyue Yang, Xiaojie He, Zulong Li, Kai Ran, Ningyu Wang, Lifeng Zhao, Zhihao Liu, Jun Zeng, Bo-Jui Chang, Qiang Feng, Qiangsheng Zhang, Luoting Yu
Topics & Concepts
Fibroblast growth factor receptor 4ChemistryMutantIndazoleIC50FGF19PharmacologySorafenibCancer researchIn vitroHepatocellular carcinomaBiochemistryStereochemistryReceptorFibroblast growth factor receptorFibroblast growth factorBiologyGeneFibroblast Growth Factor ResearchKruppel-like factors researchEpigenetics and DNA Methylation