Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction
Elisabete Augusto, Francisco Q. Gonçalves, Joana E. Real, Henrique B. Silva, Daniela Pochmann, Tiago S. Silva, Marco Matos, Nélio Gonçalves, Ângelo R. Tomé, Jiang‐Fan Chen, Paula M. Canas, Rodrigo A. Cunha
Abstract
R pathway to selectively control synaptic dysfunction and neurodegeneration following an acute brain insult, paving the way to consider CD73 as a new therapeutic target to prevent neuronal damage upon acute brain damage.
Topics & Concepts
NeurodegenerationKainate receptorAdenosine A2A receptorNeuroscienceHippocampal formationAdenosineLong-term potentiationGlutamate receptorHippocampusAdenosine receptorChemistryBiologyAMPA receptorReceptorMedicineInternal medicineBiochemistryAgonistDiseaseAdenosine and Purinergic SignalingNeuroinflammation and Neurodegeneration MechanismsNeurological Complications and Syndromes