Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-<i>s</i>-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades
Ihab Shawish, Assem Barakat, Ali Aldalbahi, Azizah M. Malebari, Mohamed S. Nafie, Adnan A. Bekhit, Amgad Albohy, Alamgir Khan, Zaheer Ul‐Haq, Matti Haukka, Beatriz G. de la Torre, Fernando Alberício, Ayman El‐Faham
Abstract
exhibited promising antiproliferative activity in HCT-116 cells through apoptosis induction by targeting the EGFR and its downstream pathway.
Topics & Concepts
ChemistryIC50Protein kinase BPI3K/AKT/mTOR pathwayMCF-7TriazineAmine gas treatingStereochemistryDocking (animal)In vitroCancer cellBiochemistrySignal transductionCancerBiologyOrganic chemistryMedicineNursingHuman breastGeneticsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activitySynthesis and Biological Evaluation