Efficient Copper-Catalysed Synthesis of Carbazoles by Double N-Arylation of Primary Amines with 2,2′-Dibromobiphenyl in the Presence of Air
Tran Quang Hung, Tuan Thanh Dang, Peter Langer, Ha Nam, Nguyễn Minh Quân, Ban Van Phuc, Dinh Van Tinh, Nguyen Quyet Tien, Truong Thi Thanh Nga, Van Tuyen Nguyen
Abstract
Abstract An efficient Cu-catalyzed synthesis of carbazole derivatives is reported, which proceeds by double C–N coupling reactions of 2,2′-dibromobiphenyl and amines in the presence of air. The reaction is robust, proceeds in high yields, and tolerates a series of amines including neutral, electron-rich, electron-deficient aromatic amines and aliphatic amines.
Topics & Concepts
ChemistryCarbazolePrimary (astronomy)CopperCatalysisOrganic chemistryMedicinal chemistryCombinatorial chemistryAstronomyPhysicsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques