Metal-Free α-C(sp<sup>3</sup>)–H Aroylation of Amines via a Photoredox Catalytic Radical–Radical Cross-Coupling Process
Guo‐Qiang Xu, Tengfei Xiao, Guo-Xuan Feng, Chen Liu, Baoxin Zhang, Peng‐Fei Xu
Abstract
)-H aroylation of amines via visible-light photoredox catalysis, which provides a straightforward route for the construction of a useful α-amino aryl ketone skeleton. Additionally, a number of selected products exhibit good biological activity for protecting PC12 cell damage, which shows that this skeleton has the potential to become a new neuroprotective agent. Finally, a series of mechanism experiments indicate that this transformation undergoes a photoredox catalytic radical-radical cross-coupling pathway.
Topics & Concepts
ChemistryPhotoredox catalysisCatalysisKetoneArylMetalPhotochemistryCombinatorial chemistryRadicalOrganic chemistryPhotocatalysisAlkylRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques