Hyaluronidase expression within tumors increases virotherapy efficacy and T cell accumulation
Martí Farrera-Sal, Rafael Moreno, Ana Mato-Berciano, María Victoria Maliandi, Miriam Bazán‐Peregrino, Ramón Alemany
Abstract
gene by P2A peptide. We demonstrate that increased hyal activity improves antitumor efficacy in both a sensitive immunodeficient model and an immunocompetent model. Moreover, we show that hyal activity impacts T cell accumulation in tumors, highlighting the value of a hyaluronidase-expressing virus for combinations with other immunotherapies in cancers involving dense stroma.
Topics & Concepts
Oncolytic virusHyaluronidaseCancer researchImmunotherapyOncolytic adenovirusBiologyChemistryImmunologyImmune systemEnzymeBiochemistryTumor cellsVirus-based gene therapy researchCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in Insects