Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse
Nyanda Elias Ntinginya, Abhishek Bakuli, Daniel Mapamba, Wilber Sabiiti, Gibson Kibiki, Lilian Tina Minja, Davis Kuchaka, Klaus Reither, Patrick Phillips, Martin J. Boeree, Stephen H. Gillespie, Michael Höelscher, Norbert Heinrich
Abstract
Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.
Topics & Concepts
MedicineTuberculosisInternal medicineMycobacterium tuberculosisGastroenterologyImmunologyMicrobiologyPathologyBiologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisInfectious Diseases and Tuberculosis