The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis
Chunhua Rui, Shen-Nan Shi, Wenqing Ren, Xia Qin, Chunlin Zhuang, Xiaofei Chen, Gang Chen, Jianqiang Yu, Hongyang Wang, Zhenyu Cai
Topics & Concepts
NecroptosisRIPK1CisplatinNephrotoxicityProgrammed cell deathPharmacologyKinaseCancer researchApoptosisChemistryMedicineKidneyChemotherapyInternal medicineBiochemistryChemotherapy-induced organ toxicity mitigationCell death mechanisms and regulationAcute Lymphoblastic Leukemia research