The neurobiology of long COVID
Michelle Monje, Akiko Iwasaki
Abstract
Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of people after COVID-19 and represent a major component of the post-acute COVID-19 syndrome, also known as long COVID. Here, we review what is understood about the pathobiology of post-acute COVID-19 impact on the CNS and discuss possible neurobiological underpinnings of the cognitive symptoms affecting COVID-19 survivors. We propose the chief mechanisms that may contribute to this emerging neurological health crisis.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Neuroscience2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PsychologyCoronavirus InfectionsBiologyVirologyMedicineDiseasePathologyOutbreakInfectious disease (medical specialty)Long-Term Effects of COVID-19Neuroinflammation and Neurodegeneration MechanismsThermal Regulation in Medicine