Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure–activity relationship and molecular modeling study
Oksana V. Salomatina, Irina I. Popadyuk, Alexandra L. Zakharenko, Olga D. Zakharova, Arina A. Chepanova, Nadezhda S. Dyrkheeva, Н. И. Комарова, Jóhannes Reynisson, Rashid O. Anarbaev, Нариман Ф. Салахутдинов, Olga I. Lavrik, Константин П. Волчо
Topics & Concepts
Deoxycholic acidMolecular modelChemistryScaffoldDNAPhosphodiesteraseBiochemistryStructure–activity relationshipStereochemistryEnzymeCombinatorial chemistryBile acidIn vitroMedicineBiomedical engineeringPhenothiazines and Benzothiazines Synthesis and ActivitiesCancer therapeutics and mechanismsSynthesis and biological activity